Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50377039
Substrate
n/a
Meas. Tech.
ChEMBL_479245 (CHEMBL932555)
IC50
0.6±n/a nM
Citation
 Xia, M; Hou, C; Demong, D; Pollack, S; Pan, M; Brackley, J; Singer, M; Matheis, M; Cavender, D; Wachter, M Substituted dipiperidine alcohols as potent CCR2 antagonists. Bioorg Med Chem Lett 18:3562-4 (2008) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50377039
Synonyms:
CHEMBL257191
Type:
Small organic molecule
Emp. Form.:
C29H33F2N3O2
Mol. Mass.:
493.588
SMILES:
OCC(C1CCN(CC1)C(=O)\C=C\c1cc(F)cc(F)c1)N1CCC(CC1)c1c[nH]c2ccccc12 |w:2.1|
Structure:
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