Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50274413
Substrate
n/a
Meas. Tech.
ChEMBL_536733 (CHEMBL984527)
Ki
1.98±n/a nM
Citation
Hatzenbuhler, NT; Baudy, R; Evrard, DA; Failli, A; Harrison, BL; Lenicek, S; Mewshaw, RE; Saab, A; Shah, U; Sze, J; Zhang, M; Zhou, D; Chlenov, M; Kagan, M; Golembieski, J; Hornby, G; Lai, M; Smith, DL; Sullivan, KM; Schechter, LE; Andree, TH Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2. J Med Chem 51:6980-7004 (2008) [PubMed] Article
More Info.:
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Human
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
Inhibitor
Name:
BDBM50274413
Synonyms:
(+)-3-[[3-(5-Cyano-1H-indol-3-yl)propyl](cyclobutyl)amino]-8-fluorochromane-5-carboxamide | (-)-3-[[3-(5-Cyano-1H-indol-3-yl)propyl](cyclobutyl)amino]-8-fluorochromane-5-carboxamide | CHEMBL485228
Type:
Small organic molecule
Emp. Form.:
C26H27FN4O2
Mol. Mass.:
446.5166
SMILES:
NC(=O)c1ccc(F)c2OCC(Cc12)N(CCCc1c[nH]c2ccc(cc12)C#N)C1CCC1