Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50309043
Substrate
n/a
Meas. Tech.
ChEMBL_612940 (CHEMBL1070892)
Ki
5.1±n/a nM
Citation
 Scott, JD; Li, SW; Wang, H; Xia, Y; Jayne, CL; Miller, MW; Duffy, RA; Boykow, GC; Kowalski, TJ; Spar, BD; Stamford, AW; Chackalamannil, S; Lachowicz, JE; Greenlee, WJ Diaryl piperidines as CB1 receptor antagonists. Bioorg Med Chem Lett 20:1278-83 (2010) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50309043
Synonyms:
CHEMBL591067 | N-(2-((3S,6S)-1-(4-chlorophenyl)-6-(2,4-dichlorophenyl)piperidin-3-yl)ethyl)-4-cyanobenzamide
Type:
Small organic molecule
Emp. Form.:
C27H24Cl3N3O
Mol. Mass.:
512.858
SMILES:
Clc1ccc(cc1)N1C[C@H](CCNC(=O)c2ccc(cc2)C#N)CC[C@H]1c1ccc(Cl)cc1Cl |r|
Structure:
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