Reaction Details Report a problem with these data
Target
Succinyl-diaminopimelate desuccinylase
Ligand
BDBM50140754
Substrate
n/a
Meas. Tech.
ChEMBL_617887 (CHEMBL1101552)
IC50
42000±n/a nM
Citation
 Gillner, D; Armoush, N; Holz, RC; Becker, DP Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity. Bioorg Med Chem Lett 19:6350-2 (2009) [PubMed]  Article 
Target
Name:
Succinyl-diaminopimelate desuccinylase
Synonyms:
DAPE_HAEIN | dapE
Type:
PROTEIN
Mol. Mass.:
41343.05
Organism:
Haemophilus influenzae
Description:
ChEMBL_617887
Residue:
377
Sequence:
MKEKVVSLAQDLIRRPSISPNDEGCQQIIAERLEKLGFQIEWMPFNDTLNLWAKHGTSEPVIAFAGHTDVVPTGDENQWSSPPFSAEIIDGMLYGRGAADMKGSLAAMIVAAEEYVKANPNHKGTIALLITSDEEATAKDGTIHVVETLMARDEKITYCMVGEPSSAKNLGDVVKNGRRGSITGNLYIQGIQGHVAYPHLAENPIHKAALFLQELTTYQWDKGNEFFPPTSLQIANIHAGTGSNNVIPAELYIQFNLRYCTEVTDEIIKQKVAEMLEKHNLKYRIEWNLSGKPFLTKPGKLLDSITSAIEETIGITPKAETGGGTSDGRFIALMGAEVVEFGPLNSTIHKVNECVSVEDLGKCGEIYHKMLVNLLDS
  
Inhibitor
Name:
BDBM50140754
Synonyms:
(R)-1-((S)-3-Mercapto-2-methyl-propionyl)-pyrrolidine-2-carboxylic acid | CHEMBL434965 | D-CAPTOPRIL
Type:
Small organic molecule
Emp. Form.:
C9H15NO3S
Mol. Mass.:
217.285
SMILES:
C[C@H](CS)C(=O)N1CCC[C@@H]1C(O)=O
Structure:
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