Reaction Details Report a problem with these data
Target
Low molecular weight protein-tyrosine phosphatase A
Ligand
BDBM50246224
Substrate
n/a
Meas. Tech.
ChEMBL_639378 (CHEMBL1167758)
Ki
9100±n/a nM
Citation
Mascarello, A; Chiaradia, LD; Vernal, J; Villarino, A; Guido, RV; Perizzolo, P; Poirier, V; Wong, D; Martins, PG; Nunes, RJ; Yunes, RA; Andricopulo, AD; Av-Gay, Y; Terenzi, H Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth. Bioorg Med Chem 18:3783-9 (2010) [PubMed] Article
More Info.:
Target
Name:
Low molecular weight protein-tyrosine phosphatase A
Synonyms:
PTPA_MYCTU | PTPase | Probable low molecular weight protein-tyrosine-phosphatase | Protein Tyrosine Phosphatase PTPA | mptpA | ptpA
Type:
Hydrolase
Mol. Mass.:
17891.84
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
n/a
Residue:
163
Sequence:
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
Inhibitor
Name:
BDBM50246224
Synonyms:
(2E)-1-(2'-Hydroxyphenyl)-3-(1-naphtyl)-2-propen-1-one | (2E)-1-(2'-hydroxyphenyl)-3-(1-naphthyl)-2-propen-1-one | 1-(2'-hydroxyphenyl)-3-(1-naphthyl)-2-propen-1-one | CHEMBL487051
Type:
Small organic molecule
Emp. Form.:
C19H14O2
Mol. Mass.:
274.3133
SMILES:
Oc1ccccc1C(=O)\C=C\c1cccc2ccccc12