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Target
Kynurenine--oxoglutarate transaminase 3
Ligand
BDBM50386292
Substrate
n/a
Meas. Tech.
ChEMBL_826601 (CHEMBL2050769)
IC50
11000±n/a nM
Citation
 Dounay, AB; Anderson, M; Bechle, BM; Campbell, BM; Claffey, MM; Evdokimov, A; Evrard, E; Fonseca, KR; Gan, X; Ghosh, S; Hayward, MM; Horner, W; Kim, JY; McAllister, LA; Pandit, J; Paradis, V; Parikh, VD; Reese, MR; Rong, S; Salafia, MA; Schuyten, K; Strick, CA; Tuttle, JB; Valentine, J; Wang, H; Zawadzke, LE; Verhoest, PR Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. ACS Med Chem Lett 3:187-192 (2012) [PubMed]  Article 
Target
Name:
Kynurenine--oxoglutarate transaminase 3
Synonyms:
CCBL2 | Cysteine-S-conjugate beta-lyase 2 | KAT3 | KAT3_HUMAN | KATIII | KYAT3 | Kynurenine aminotransferase III | Kynurenine--glyoxylate transaminase | Kynurenine--oxoglutarate transaminase III
Type:
PROTEIN
Mol. Mass.:
51406.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_939752
Residue:
454
Sequence:
MFLAQRSLCSLSGRAKFLKTISSSKILGFSTSAKMSLKFTNAKRIEGLDSNVWIEFTKLAADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPVYGKRWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRDRMVRLLESVGLKPIVPDGGYFIIADVSLLDPDLSDMKNNEPYDYKFVKWMTKHKKLSAIPVSAFCNSETKSQFEKFVRFCFIKKDSTLDAAEEIIKAWSVQKS
  
Inhibitor
Name:
BDBM50386292
Synonyms:
CHEMBL2047851
Type:
Small organic molecule
Emp. Form.:
C9H10N2O2
Mol. Mass.:
178.1879
SMILES:
N[C@H]1Cc2ccccc2N(O)C1=O |r|
Structure:
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