Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50386723
Substrate
n/a
Meas. Tech.
ChEMBL_826608 (CHEMBL2050862)
Ki
10.2±n/a nM
Citation
 Gitto, R; Damiano, FM; Mader, P; De Luca, L; Ferro, S; Supuran, CT; Vullo, D; Brynda, J; Rezácová, P; Chimirri, A Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors. J Med Chem 55:3891-9 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50386723
Synonyms:
CHEMBL2048925
Type:
Small organic molecule
Emp. Form.:
C16H16N2O3S
Mol. Mass.:
316.375
SMILES:
COc1ccc2C(=NCCc2c1)c1ccc(cc1)S(N)(=O)=O |c:6|
Structure:
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