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Target
Peptidyl-prolyl cis-trans isomerase FKBP4
Ligand
BDBM50388270
Substrate
n/a
Meas. Tech.
ChEMBL_829706 (CHEMBL2061146)
IC50
15130±n/a nM
Citation
 Gopalakrishnan, R; Kozany, C; Wang, Y; Schneider, S; Hoogeland, B; Bracher, A; Hausch, F Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52. J Med Chem 55:4123-31 (2012) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP4
Synonyms:
FK506 binding protein 4 | FKBP4 | FKBP4_HUMAN | FKBP52
Type:
PROTEIN
Mol. Mass.:
51793.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_154482
Residue:
459
Sequence:
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
  
Inhibitor
Name:
BDBM50388270
Synonyms:
CHEMBL2058800
Type:
Small organic molecule
Emp. Form.:
C29H33Cl2N3O5S
Mol. Mass.:
606.56
SMILES:
Oc1c(Cl)cc(cc1Cl)S(=O)(=O)N1CCCC[C@H]1C(=O)OC(CCCc1cccnc1)CCCc1cccnc1 |r|
Structure:
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