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Target
Cytochrome P450 2B6
Ligand
BDBM50396084
Substrate
n/a
Meas. Tech.
ChEMBL_861850 (CHEMBL2173506)
IC50
54000±n/a nM
Citation
 Spadaro, A; Frotscher, M; Hartmann, RW Optimization of hydroxybenzothiazoles as novel potent and selective inhibitors of 17ß-HSD1. J Med Chem 55:2469-73 (2012) [PubMed]  Article 
Target
Name:
Cytochrome P450 2B6
Synonyms:
CP2B6_HUMAN | CYP2B6 | Cytochrome P450 2B6 (CYP2B6)
Type:
Protein
Mol. Mass.:
56289.75
Organism:
Human
Description:
P20813
Residue:
491
Sequence:
MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR
  
Inhibitor
Name:
BDBM50396084
Synonyms:
CHEMBL2170750
Type:
Small organic molecule
Emp. Form.:
C14H8FNO3S
Mol. Mass.:
289.282
SMILES:
Oc1ccc2nc(sc2c1)C(=O)c1ccc(F)c(O)c1
Structure:
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