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Target
Mitogen-activated protein kinase 10
Ligand
BDBM50411419
Substrate
n/a
Meas. Tech.
ChEMBL_446769 (CHEMBL897068)
IC50
1000±n/a nM
Citation
 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett 17:1296-301 (2007) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 10
Synonyms:
JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3)
Type:
Enzyme
Mol. Mass.:
52586.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
464
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
  
Inhibitor
Name:
BDBM50411419
Synonyms:
CHEMBL233002 | SB-814597
Type:
Small organic molecule
Emp. Form.:
C20H15FN2OS
Mol. Mass.:
350.409
SMILES:
Fc1ccc(C(=O)Nc2sc3CCCCc3c2C#N)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: