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Target
Vasopressin V1a receptor
Ligand
BDBM50413714
Substrate
n/a
Meas. Tech.
ChEMBL_540348 (CHEMBL1025691)
Ki
15.85±n/a nM
Citation
 Barton, NP; Bellenie, BR; Doran, AT; Emmons, AJ; Heer, JP; Salvagno, CM Discovery and optimisation of a potent and selective tertiary sulfonamide oxytocin antagonist. Bioorg Med Chem Lett 19:528-32 (2008) [PubMed]  Article 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM50413714
Synonyms:
CHEMBL458635
Type:
Small organic molecule
Emp. Form.:
C26H25N3O4S
Mol. Mass.:
475.559
SMILES:
COc1ccc(cc1)S(=O)(=O)N(Cc1ccc(cn1)-c1ccccc1C)c1ccc(OC)nc1
Structure:
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