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Target
Cannabinoid receptor 1
Ligand
BDBM50160112
Substrate
n/a
Meas. Tech.
ChEMBL_500314 (CHEMBL973406)
IC50
6.31±n/a nM
Citation
 Kang, NS; Lee, GN; Yoo, SE Predictive models of Cannabinoid-1 receptor antagonists derived from diverse classes. Bioorg Med Chem Lett 19:2990-6 (2009) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50160112
Synonyms:
6-(2,4-Dichloro-phenyl)-2-(3,4-difluoro-benzyloxy)-5-p-tolyl-nicotinonitrile | 6-(2,4-dichlorophenyl)-2-(3,4-difluorobenzyloxy)-5-p-tolylnicotinonitrile | CHEMBL181629
Type:
Small organic molecule
Emp. Form.:
C26H16Cl2F2N2O
Mol. Mass.:
481.321
SMILES:
Cc1ccc(cc1)-c1cc(C#N)c(OCc2ccc(F)c(F)c2)nc1-c1ccc(Cl)cc1Cl
Structure:
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