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Target
Histone deacetylase 1
Ligand
BDBM50426495
Substrate
n/a
Meas. Tech.
ChEMBL_938236 (CHEMBL2328659)
IC50
17600±n/a nM
Citation
 Li, X; Tu, Z; Li, H; Liu, C; Li, Z; Sun, Q; Yao, Y; Liu, J; Jiang, S Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry. ACS Med Chem Lett 4:132-6 (2013) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50426495
Synonyms:
CHEMBL2323289
Type:
Small organic molecule
Emp. Form.:
C28H40N6O5S2
Mol. Mass.:
604.784
SMILES:
CCCCCCCC(=O)SCC\C=C\[C@@H]1CC(=O)NCc2nc(cs2)-c2cn(CC(=O)N[C@@H](C(C)C)C(=O)O1)nn2 |r|
Structure:
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