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Target
Proteasome subunit beta type-5
Ligand
BDBM50430965
Substrate
n/a
Meas. Tech.
ChEMBL_946840 (CHEMBL2345505)
IC50
9400±n/a nM
Citation
 Desvergne, A; Genin, E; Maréchal, X; Gallastegui, N; Dufau, L; Richy, N; Groll, M; Vidal, J; Reboud-Ravaux, M Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome. J Med Chem 56:3367-78 (2013) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
DOA3 | PRE2 | PRG1 | PSB5_YEAST | Proteasome Macropain subunit PRE2
Type:
PROTEIN
Mol. Mass.:
31634.72
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_946840
Residue:
287
Sequence:
MQAIADSFSVPNRLVKELQYDNEQNLESDFVTGASQFQRLAPSLTVPPIASPQQFLRAHTDDSRNPDCKIKIAHGTTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG
  
Inhibitor
Name:
BDBM50430965
Synonyms:
CHEMBL2337850
Type:
Small organic molecule
Emp. Form.:
C37H39N5O6
Mol. Mass.:
649.7355
SMILES:
C[C@H](NC(=O)[C@@H](N)Cc1ccc(OCc2ccccc2)cc1)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1 |r|
Structure:
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