Reaction Details Report a problem with these data
Target
Acid ceramidase
Ligand
BDBM50431260
Substrate
n/a
Meas. Tech.
ChEMBL_949261 (CHEMBL2346137)
IC50
13±n/a nM
Citation
Pizzirani, D; Pagliuca, C; Realini, N; Branduardi, D; Bottegoni, G; Mor, M; Bertozzi, F; Scarpelli, R; Piomelli, D; Bandiera, T Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). J Med Chem 56:3518-30 (2013) [PubMed] Article
More Info.:
Target
Name:
Acid ceramidase
Synonyms:
AC | ACDase | ASAH1_RAT | Acid CDase | Acid ceramidase | Acid ceramidase (AC) | Acylsphingosine deacylase | Asah1 | N-acylsphingosine amidohydrolase
Type:
Enzyme
Mol. Mass.:
44450.22
Organism:
Rattus norvegicus (Rat)
Description:
Q6P7S1
Residue:
394
Sequence:
MLGRSLLTWVLAAAVTCAQAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKRWHELLAHKAPVLRTLVNSISNLVNAFVPSGKIMQMVDEKLPGLIGSIPGPFGEEMRGIADVTGIPLGEIISFNIFYELFTMCTSIITEDGKGHLLHGRNMDFGIFLGWNINNNTWVVTEELKPLTVNLDFQRNNKTVFKATSFAGYVGMLTGFKPGLLSLTLNERFSLNGGYLGILEWMFGKKNAQWVGFITRSVLENSTSYEEAKNILTKTKITAPAYFILGGNQSGEGCVITRERKESLDVYELDPKHGRWYVVQTNYDRWKNTLFLDDRRTPAKKCLNHTTQKNLSFATIYDVLSTKPVLNKLTVFTTLIDVTKDQFESHLRDCPDPCIGW