Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50432189
Substrate
n/a
Meas. Tech.
ChEMBL_950672 (CHEMBL2352675)
Ki
107±n/a nM
Citation
 Madadi, NR; Penthala, NR; Brents, LK; Ford, BM; Prather, PL; Crooks, PA Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors. Bioorg Med Chem Lett 23:2019-21 (2013) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50432189
Synonyms:
CHEMBL2346981
Type:
Small organic molecule
Emp. Form.:
C23H22ClN3O
Mol. Mass.:
391.893
SMILES:
Clc1ccc(Cn2cc(CC3=C(N=O)C4CCN3CC4)c3ccccc23)cc1 |c:10,(14.54,-59.36,;15.36,-58.05,;14.64,-56.69,;15.45,-55.39,;16.99,-55.44,;17.81,-54.14,;17.08,-52.78,;17.99,-51.53,;17.08,-50.29,;17.56,-48.82,;19.06,-48.5,;19.53,-47.05,;18.51,-45.9,;18.98,-44.44,;21.05,-46.73,;22.08,-47.88,;21.59,-49.34,;20.09,-49.66,;20.17,-48.02,;20.99,-47.96,;15.62,-50.76,;14.28,-50,;12.95,-50.77,;12.95,-52.31,;14.28,-53.08,;15.62,-52.3,;17.71,-56.8,;16.9,-58.1,)|
Structure:
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