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Target
Tyrosine-protein kinase Mer
Ligand
BDBM50444080
Substrate
n/a
Meas. Tech.
ChEMBL_1279519 (CHEMBL3097238)
IC50
2.8±n/a nM
Citation
 Zhang, W; Zhang, D; Stashko, MA; DeRyckere, D; Hunter, D; Kireev, D; Miley, MJ; Cummings, C; Lee, M; Norris-Drouin, J; Stewart, WM; Sather, S; Zhou, Y; Kirkpatrick, G; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J Med Chem 56:9683-92 (2014) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Human
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM50444080
Synonyms:
CHEMBL3092805
Type:
Small organic molecule
Emp. Form.:
C24H37N7O
Mol. Mass.:
439.5969
SMILES:
CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(cn1)N1CCN(C)CC1 |r,wU:11.10,wD:14.14,(13.34,-23.32,;14.67,-22.55,;16,-23.32,;17.34,-22.56,;18.67,-23.33,;20.01,-22.56,;21.34,-23.33,;22.68,-22.56,;22.67,-21.01,;21.34,-20.24,;21.33,-18.7,;20,-17.94,;18.67,-18.71,;17.33,-17.93,;17.33,-16.39,;16,-15.62,;18.67,-15.62,;20,-16.39,;20.01,-21.01,;24,-20.23,;25.33,-21,;26.66,-20.23,;26.66,-18.69,;25.31,-17.92,;23.99,-18.7,;27.99,-17.91,;29.31,-18.68,;30.64,-17.91,;30.64,-16.37,;31.97,-15.6,;29.3,-15.6,;27.97,-16.37,)|
Structure:
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