Reaction Details Report a problem with these data
Target
P2Y purinoceptor 1
Ligand
BDBM50444473
Substrate
n/a
Meas. Tech.
ChEMBL_1277497 (CHEMBL3096017)
Ki
1100±n/a nM
Citation
 Ruel, R; L'Heureux, A; Thibeault, C; Lapointe, P; Martel, A; Qiao, JX; Hua, J; Price, LA; Wu, Q; Chang, M; Zheng, J; Huang, CS; Wexler, RR; Rehfuss, R; Lam, PY Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds. Bioorg Med Chem Lett 23:6825-8 (2013) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 1
Synonyms:
ATP receptor | P2RY1 | P2RY1_HUMAN | P2Y purinoceptor 1 (P2Y1) | P2Y1 | Purinergic receptor | Purinergic receptor P2Y1
Type:
Enzyme
Mol. Mass.:
42090.25
Organism:
Homo sapiens (Human)
Description:
P47900
Residue:
373
Sequence:
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL
  
Inhibitor
Name:
BDBM50444473
Synonyms:
CHEMBL3092622
Type:
Small organic molecule
Emp. Form.:
C28H24F3N5O3
Mol. Mass.:
535.5171
SMILES:
FC(F)(F)Oc1ccc(NC(=O)Nc2cccnc2Oc2cccc3CN(Cc4ccccn4)CCc23)cc1
Structure:
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