Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM50444620
Substrate
n/a
Meas. Tech.
ChEMBL_1283184 (CHEMBL3101095)
Ki
17±n/a nM
Citation
 Mercer, SP; Roecker, AJ; Garson, S; Reiss, DR; Meacham Harrell, C; Murphy, KL; Bruno, JG; Bednar, RA; Lemaire, W; Cui, D; Cabalu, TD; Tang, C; Prueksaritanont, T; Hartman, GD; Young, SD; Winrow, CJ; Renger, JJ; Coleman, PJ Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs). Bioorg Med Chem Lett 23:6620-4 (2013) [PubMed]  Article 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM50444620
Synonyms:
CHEMBL3099884
Type:
Small organic molecule
Emp. Form.:
C27H23N3O3
Mol. Mass.:
437.4898
SMILES:
Cc1cc(C)cc(c1)-c1cnc(-c2cccnc2)c(c1)C(=O)NCc1ccc2OCOc2c1
Structure:
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