Reaction Details Report a problem with these data
Target
ATP-dependent 6-phosphofructokinase
Ligand
BDBM50446088
Substrate
n/a
Meas. Tech.
ChEMBL_1288121 (CHEMBL3110581)
IC50
15±n/a nM
Citation
Brimacombe, KR; Walsh, MJ; Liu, L; Vásquez-Valdivieso, MG; Morgan, HP; McNae, I; Fothergill-Gilmore, LA; Michels, PA; Auld, DS; Simeonov, A; Walkinshaw, MD; Shen, M; Boxer, MB Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett 5:12-7 (2014) [PubMed] Article
More Info.:
Target
Name:
ATP-dependent 6-phosphofructokinase
Synonyms:
6-phospho-1-fructokinase | PFKA_TRYBB | pfk
Type:
PROTEIN
Mol. Mass.:
53537.94
Organism:
Trypanosoma brucei
Description:
ChEMBL_1288121
Residue:
487
Sequence:
MAVESRSRVTSKLVKAHRAMLNSVTQEDLKVDRLPGADYPNPSKKYSSRTEFRDKTDYIMYNPRPRDEPSSENPVSVSPLLCELAAARSRIHFNPTETTIGIVTCGGICPGLNDVIRSITLTGINVYNVKRVIGFRFGYWGLSKKGSQTAIELHRGRVTNIHHYGGTILGSSRGPQDPKEMVDTLERLGVNILFTVGGDGTQRGALVISQEAKRRGVDISVFGVPKTIDNDLSFSHRTFGFQTAVEKAVQAIRAAYAEAVSANYGVGVVKLMGRDSGFIAAQAAVASAQANICLVPENPISEQEVMSLLERRFCHSRSCVIIVAEGFGQDWGRGSGGYDASGNKKLIDIGVILTEKVKAFLKANKSRYPDSTVKYIDPSYMIRACPPSANDALFCATLATLAVHEAMAGATGCIIAMRHNNYILVPIKVATSVRRVLDLRGQLWRQVREITVDLGSDVRLARKLEIRRELEAINRNRDRLHEELAKL