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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50006617
Substrate
n/a
Meas. Tech.
ChEMBL_1335291 (CHEMBL3238715)
Ki
0.200000±n/a nM
Citation
 Gao, Y; Kellar, KJ; Yasuda, RP; Tran, T; Xiao, Y; Dannals, RF; Horti, AG Derivatives of dibenzothiophene for positron emission tomography imaging ofa7-nicotinic acetylcholine receptors. J Med Chem 56:7574-89 (2013) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50006617
Synonyms:
CHEMBL3235490
Type:
Small organic molecule
Emp. Form.:
C19H19FN2O
Mol. Mass.:
309.3679
SMILES:
[18F]c1ccccc1-c1cnc2OC3(Cc2c1)CN1CCC3CC1 |TLB:13:12:18.19:22.21,THB:11:12:18.19:22.21,(37.37,-32.12,;38.71,-31.35,;40.04,-32.13,;41.39,-31.36,;41.38,-29.82,;40.06,-29.05,;38.72,-29.81,;37.39,-29.04,;37.4,-27.5,;36.07,-26.73,;34.72,-27.49,;33.25,-27.02,;32.35,-28.27,;33.26,-29.52,;34.73,-29.04,;36.06,-29.8,;32,-29.62,;30.55,-28.8,;29.11,-29.28,;29.55,-27.92,;30.96,-27.47,;31.07,-25.83,;30.5,-26.88,)|
Structure:
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