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Target
Proteinase-activated receptor 4
Ligand
BDBM50024252
Substrate
n/a
Meas. Tech.
ChEMBL_1435253 (CHEMBL3390699)
IC50
140±n/a nM
Citation
 Wen, W; Young, SE; Duvernay, MT; Schulte, ML; Nance, KD; Melancon, BJ; Engers, J; Locuson, CW; Wood, MR; Daniels, JS; Wu, W; Lindsley, CW; Hamm, HE; Stauffer, SR Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. Bioorg Med Chem Lett 24:4708-13 (2014) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM50024252
Synonyms:
CHEMBL1609104
Type:
Small organic molecule
Emp. Form.:
C16H14N2O3
Mol. Mass.:
282.294
SMILES:
Cn1c(CO)c(-c2ccccc2)c2cc(ccc12)[N+]([O-])=O
Structure:
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