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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50026177
Substrate
n/a
Meas. Tech.
ChEMBL_1438933 (CHEMBL3382444)
EC50
23±n/a nM
Citation
 Wacker, DA; Wang, Y; Broekema, M; Rossi, K; O'Connor, S; Hong, Z; Wu, G; Malmstrom, SE; Hung, CP; LaMarre, L; Chimalakonda, A; Zhang, L; Xin, L; Cai, H; Chu, C; Boehm, S; Zalaznick, J; Ponticiello, R; Sereda, L; Han, SP; Zebo, R; Zinker, B; Luk, CE; Wong, R; Everlof, G; Li, YX; Wu, CK; Lee, M; Griffen, S; Miller, KJ; Krupinski, J; Robl, JA Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119. J Med Chem 57:7499-508 (2014) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Human
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50026177
Synonyms:
CHEMBL3338173
Type:
Small organic molecule
Emp. Form.:
C24H26N4O4S
Mol. Mass.:
466.553
SMILES:
CS(=O)(=O)c1ccc(cc1)-n1ccc(OC2CCN(CC2)c2ncc(cn2)C2CC2)cc1=O
Structure:
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