Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50029970
Substrate
n/a
Meas. Tech.
ChEMBL_1438384 (CHEMBL3383059)
Ki
129±n/a nM
Citation
 Lucchesi, V; Hurst, DP; Shore, DM; Bertini, S; Ehrmann, BM; Allarà, M; Lawrence, L; Ligresti, A; Minutolo, F; Saccomanni, G; Sharir, H; Macchia, M; Di Marzo, V; Abood, ME; Reggio, PH; Manera, C CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides. J Med Chem 57:8777-91 (2014) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50029970
Synonyms:
CHEMBL3353426
Type:
Small organic molecule
Emp. Form.:
C19H25N3O3
Mol. Mass.:
343.4201
SMILES:
CC1CCC(CC1)NC(=O)c1cc2cccnc2n(CCCO)c1=O |(9.73,-10.05,;8.4,-10.82,;8.4,-12.36,;7.08,-13.13,;5.73,-12.36,;5.73,-10.83,;7.06,-10.05,;4.41,-13.14,;3.07,-12.38,;3.06,-10.84,;1.74,-13.16,;.4,-12.4,;-.93,-13.17,;-2.27,-12.4,;-3.6,-13.18,;-3.6,-14.72,;-2.27,-15.49,;-.93,-14.71,;.41,-15.48,;.42,-17.02,;1.75,-17.79,;1.75,-19.33,;3.09,-20.09,;1.75,-14.7,;3.08,-15.47,)|
Structure:
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