Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50030078
Substrate
n/a
Meas. Tech.
ChEMBL_1438384 (CHEMBL3383059)
Ki
27±n/a nM
Citation
 Lucchesi, V; Hurst, DP; Shore, DM; Bertini, S; Ehrmann, BM; Allarà, M; Lawrence, L; Ligresti, A; Minutolo, F; Saccomanni, G; Sharir, H; Macchia, M; Di Marzo, V; Abood, ME; Reggio, PH; Manera, C CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides. J Med Chem 57:8777-91 (2014) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50030078
Synonyms:
CHEMBL3353432
Type:
Small organic molecule
Emp. Form.:
C22H29N3O4
Mol. Mass.:
399.4834
SMILES:
COC(=O)CCCCn1c2ncccc2cc(C(=O)NC2CCC(C)CC2)c1=O |(20.77,-12.69,;20.77,-11.15,;19.43,-10.38,;18.1,-11.15,;19.43,-8.84,;18.09,-8.07,;18.09,-6.53,;16.76,-5.76,;16.75,-4.22,;15.42,-3.46,;14.08,-4.24,;12.75,-3.47,;12.75,-1.92,;14.08,-1.15,;15.42,-1.91,;16.74,-1.14,;18.08,-1.9,;19.41,-1.12,;19.4,.42,;20.75,-1.89,;22.08,-1.11,;23.42,-1.88,;24.74,-1.11,;24.74,.44,;26.07,1.22,;23.4,1.21,;22.07,.43,;18.09,-3.45,;19.42,-4.22,)|
Structure:
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