Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-alpha
Ligand
BDBM50034788
Substrate
n/a
Meas. Tech.
ChEMBL_1441018 (CHEMBL3377014)
EC50
18±n/a nM
Citation
 Kick, E; Martin, R; Xie, Y; Flatt, B; Schweiger, E; Wang, TL; Busch, B; Nyman, M; Gu, XH; Yan, G; Wagner, B; Nanao, M; Nguyen, L; Stout, T; Plonowski, A; Schulman, I; Ostrowski, J; Kirchgessner, T; Wexler, R; Mohan, R Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRß. Bioorg Med Chem Lett 25:372-7 (2014) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50034788
Synonyms:
CHEMBL3360963
Type:
Small organic molecule
Emp. Form.:
C22H15F5N2O2S2
Mol. Mass.:
498.489
SMILES:
CS(=O)(=O)c1cccc(c1)-c1ccc(s1)-c1cc(nn1Cc1ccc(F)cc1F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: