Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50042016
Substrate
n/a
Meas. Tech.
ChEMBL_1443856 (CHEMBL3373530)
IC50
10.0±n/a nM
Citation
Naidu, BN; Sorenson, ME; Patel, M; Ueda, Y; Banville, J; Beaulieu, F; Bollini, S; Dicker, IB; Higley, H; Lin, Z; Pajor, L; Parker, DD; Terry, BJ; Zheng, M; Martel, A; Meanwell, NA; Krystal, M; Walker, MA Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors. Bioorg Med Chem Lett 25:717-20 (2015) [PubMed] Article
More Info.:
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus type 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED