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Target
Histone deacetylase
Ligand
BDBM50047418
Substrate
n/a
Meas. Tech.
ChEMBL_1450204 (CHEMBL3375767)
IC50
3.4±n/a nM
Citation
 McCoull, W; Barton, P; Brown, AJ; Bowker, SS; Cameron, J; Clarke, DS; Davies, RD; Dossetter, AG; Ertan, A; Fenwick, M; Green, C; Holmes, JL; Martin, N; Masters, D; Moore, JE; Newcombe, NJ; Newton, C; Pointon, H; Robb, GR; Sheldon, C; Stokes, S; Morgan, D Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. J Med Chem 57:6128-40 (2014) [PubMed]  Article 
Target
Name:
Histone deacetylase
Synonyms:
Hdac5 | Hdac5 protein
Type:
PROTEIN
Mol. Mass.:
34754.92
Organism:
Rattus norvegicus
Description:
ChEMBL_104809
Residue:
328
Sequence:
MHSSSAVRMAVGCLVELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLSVGKVLIVDWDIHHGNGTQQAFYDDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPSINAVATLEKVIEIQSKHWSCVQRFATGLGCSLREAQTGEKEEAETVSAMALLSMGAEQAQAAATQEHSPRPAEEPMEQEPAL
  
Inhibitor
Name:
BDBM50047418
Synonyms:
CHEMBL3319223
Type:
Small organic molecule
Emp. Form.:
C27H33ClN6O5S2
Mol. Mass.:
621.171
SMILES:
CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(ccc4Cl)N4CCOCC4)sc3c2)CC1
Structure:
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