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Target
Scavenger receptor class B member 1
Ligand
BDBM50069742
Substrate
n/a
Meas. Tech.
ChEMBL_1466965 (CHEMBL3406604)
IC50
2000±n/a nM
Citation
 Dockendorff, C; Faloon, PW; Pu, J; Yu, M; Johnston, S; Bennion, M; Penman, M; Nieland, TJ; Dandapani, S; Perez, JR; Munoz, B; Palmer, MA; Schreiber, SL; Krieger, M Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Bioorg Med Chem Lett 25:2100-5 (2015) [PubMed]  Article 
Target
Name:
Scavenger receptor class B member 1
Synonyms:
SCRB1_MOUSE | SR-BI | Scarb1 | Scavenger receptor class B member 1 | Srb1
Type:
PROTEIN
Mol. Mass.:
56761.39
Organism:
Mus musculus
Description:
ChEMBL_103999
Residue:
509
Sequence:
MGGSSRARWVALGLGALGLLFAALGVVMILMVPSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPNEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSFVENRSLHFQPDKSHGSESDYIVLPNILVLGGSILMESKPVSLKLMMTLALVTMGQRAFMNRTVGEILWGYDDPFVHFLNTYLPDMLPIKGKFGLFVGMNNSNSGVFTVFTGVQNFSRIHLVDKWNGLSKIDYWHSEQCNMINGTSGQMWAPFMTPESSLEFFSPEACRSMKLTYNESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTCRFGAPLFLSHPHFYNADPVLSEAVLGLNPNPKEHSLFLDIHPVTGIPMNCSVKMQLSLYIKSVKGIGQTGKIEPVVLPLLWFEQSGAMGGKPLSTFYTQLVLMPQVLHYAQYVLLGLGGLLLLVPIICQLRSQEKCFLFWSGSKKGSQDKEAIQAYSESLMSPAAKGTVLQEAKL
  
Inhibitor
Name:
BDBM50069742
Synonyms:
CHEMBL3400862
Type:
Small organic molecule
Emp. Form.:
C34H40N4O7S
Mol. Mass.:
648.769
SMILES:
COc1ccc(cc1)S(=O)(=O)N(C)C[C@@H]1Oc2ccc(NC(=O)Cc3cn(C)c4ccccc34)cc2C(=O)N(C[C@H]1C)[C@H](C)CO |r|
Structure:
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