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Target
Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain
Ligand
BDBM50098799
Substrate
n/a
Meas. Tech.
ChEMBL_1504929 (CHEMBL3595578)
IC50
8200±n/a nM
Citation
 Lee, HY; Chang, CY; Lai, MJ; Chuang, HY; Kuo, CC; Chang, CY; Chang, JY; Liou, JP Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes. Bioorg Med Chem 23:4230-6 (2015) [PubMed]  Article 
Target
Name:
Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain
Synonyms:
Tubulin | Tubulin alpha chain /beta chain
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 51441
Components:
This complex has 2 components.
Component 1
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Component 2
Name:
Similar to alpha-tubulin isoform 1
Synonyms:
Tubulin
Type:
PROTEIN
Mol. Mass.:
9422.48
Organism:
Bos taurus
Description:
EBI_18002
Residue:
84
Sequence:
PSPQVSTAVVEPYNSILTTKHLEHSDCFMVDNEAIYDICRRNLDIERPTTRNLNRLMSQIVSSITASLRFDGALTVDLTDVQTS
  
Inhibitor
Name:
BDBM50098799
Synonyms:
CHEMBL3593871
Type:
Small organic molecule
Emp. Form.:
C19H19NO5
Mol. Mass.:
341.3579
SMILES:
COc1cc(C(=O)c2cccc3n(C)ccc23)c(O)c(OC)c1OC
Structure:
Search PDB for entries with ligand similarity: