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Target
Low molecular weight phosphotyrosine protein phosphatase
Ligand
BDBM50102748
Substrate
n/a
Meas. Tech.
ChEMBL_1443134 (CHEMBL3371694)
IC50
16400±n/a nM
Citation
 Ramírez-Espinosa, JJ; Rios, MY; Paoli, P; Flores-Morales, V; Camici, G; de la Rosa-Lugo, V; Hidalgo-Figueroa, S; Navarrete-Vázquez, G; Estrada-Soto, S Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition. Eur J Med Chem 87:316-27 (2014) [PubMed]  Article 
Target
Name:
Low molecular weight phosphotyrosine protein phosphatase
Synonyms:
3.1.3.2 | 3.1.3.48 | ACP1 | Adipocyte acid phosphatase | LMW-PTP | LMW-PTPase | LMWPTP | Low molecular weight cytosolic acid phosphatase | PPAC_HUMAN | Red cell acid phosphatase 1 | low molecular weight phosphotyrosine protein phosphatase isoform c
Type:
n/a
Mol. Mass.:
18042.81
Organism:
Homo sapiens (Human)
Description:
P24666
Residue:
158
Sequence:
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
  
Inhibitor
Name:
BDBM50102748
Synonyms:
CHEMBL3343064
Type:
Small organic molecule
Emp. Form.:
C32H52O3
Mol. Mass.:
484.7535
SMILES:
[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](OCC)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O |r,t:15|
Structure:
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