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Target
Monoglyceride lipase
Ligand
BDBM50118166
Substrate
n/a
Meas. Tech.
ChEMBL_1514638 (CHEMBL3614385)
IC50
520±n/a nM
Citation
 Patel, JZ; van Bruchem, J; Laitinen, T; Kaczor, AA; Navia-Paldanius, D; Parkkari, T; Savinainen, JR; Laitinen, JT; Nevalainen, TJ Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors. Bioorg Med Chem 23:6335-45 (2015) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Human
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50118166
Synonyms:
CHEMBL3613663
Type:
Small organic molecule
Emp. Form.:
C17H16N2O4
Mol. Mass.:
312.3199
SMILES:
COc1nn(Cc2ccc(OCc3ccccc3)cc2)c(=O)o1
Structure:
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