Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50119387
Substrate
n/a
Meas. Tech.
ChEMBL_1515737 (CHEMBL3614290)
Ki
35±n/a nM
Citation
 Möller, D; Salama, I; Kling, RC; Hübner, H; Gmeiner, P 1,4-Disubstituted aromatic piperazines with high 5-HT2A/D2 selectivity: Quantitative structure-selectivity investigations, docking, synthesis and biological evaluation. Bioorg Med Chem 23:6195-209 (2015) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50119387
Synonyms:
CHEMBL140968 | N-(5-(4-(2-methoxyphenyl)piperazin-1-yl)pentyl)H-pyrazolo[1,5-a]pyridine-2-carboxamide | Pyrazolo[1,5-a]pyridine-2-carboxylic acid {5-[4-(2-methoxy-phenyl)-piperazin-1-yl]-pentyl}-amide
Type:
Small organic molecule
Emp. Form.:
C24H31N5O2
Mol. Mass.:
421.5352
SMILES:
COc1ccccc1N1CCN(CCCCCNC(=O)c2cc3ccccn3n2)CC1
Structure:
Search PDB for entries with ligand similarity: