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Target
Cytochrome P450 26A1
Ligand
BDBM50162789
Substrate
n/a
Meas. Tech.
ChEMBL_1517856 (CHEMBL3620652)
IC50
50±n/a nM
Citation
 Sun, B; Liu, K; Han, J; Zhao, LY; Su, X; Lin, B; Zhao, DM; Cheng, MS Design, synthesis, and biological evaluation of amide imidazole derivatives as novel metabolic enzyme CYP26A1 inhibitors. Bioorg Med Chem 23:6763-73 (2015) [PubMed]  Article 
Target
Name:
Cytochrome P450 26A1
Synonyms:
CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase
Type:
Enzyme
Mol. Mass.:
56216.16
Organism:
Homo sapiens (Human)
Description:
O43174
Residue:
497
Sequence:
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI
  
Inhibitor
Name:
BDBM50162789
Synonyms:
CHEMBL180856 | [2-(6-Benzyloxy-naphthalen-2-yl)-2-imidazol-1-yl-1-methyl-ethyl]-dimethyl-amine
Type:
Small organic molecule
Emp. Form.:
C25H27N3O
Mol. Mass.:
385.5014
SMILES:
CC(C(c1ccc2cc(OCc3ccccc3)ccc2c1)n1ccnc1)N(C)C
Structure:
Search PDB for entries with ligand similarity: