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Target
Orexin receptor type 2
Ligand
BDBM50120895
Substrate
n/a
Meas. Tech.
ChEMBL_1520598 (CHEMBL3625146)
IC50
245±n/a nM
Citation
 Roecker, AJ; Mercer, SP; Bergman, JM; Gilbert, KF; Kuduk, SD; Harrell, CM; Garson, SL; Fox, SV; Gotter, AL; Tannenbaum, PL; Prueksaritanont, T; Cabalu, TD; Cui, D; Lemaire, W; Winrow, CJ; Renger, JJ; Coleman, PJ Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements. Bioorg Med Chem Lett 25:4992-9 (2015) [PubMed]  Article 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM50120895
Synonyms:
CHEMBL3622337
Type:
Small organic molecule
Emp. Form.:
C21H22F3N7O2
Mol. Mass.:
461.4403
SMILES:
COc1ncc(c(n1)N1CC[C@@H](C)N(CC1)C(=O)c1ccccc1-n1nccn1)C(F)(F)F |r|
Structure:
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