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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM21354
Substrate
n/a
Meas. Tech.
ChEMBL_1521956 (CHEMBL3626980)
Ki
6.0±n/a nM
Citation
 Karila, D; Freret, T; Bouet, V; Boulouard, M; Dallemagne, P; Rochais, C Therapeutic Potential of 5-HT6 Receptor Agonists. J Med Chem 58:7901-12 (2015) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM21354
Synonyms:
2-{1-[(5-chlorothiophene-2-)sulfonyl]-1H-indol-3-yl}ethan-1-amine | thiophene sulfonyltryptamine, 11m
Type:
Small organic molecule
Emp. Form.:
C14H13ClN2O2S2
Mol. Mass.:
340.848
SMILES:
NCCc1cn(c2ccccc12)S(=O)(=O)c1ccc(Cl)s1
Structure:
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