Reaction Details Report a problem with these data
Target
Glycylpeptide N-tetradecanoyltransferase 1
Ligand
BDBM50135488
Substrate
n/a
Meas. Tech.
ChEMBL_1549624 (CHEMBL3756684)
Ki
24±n/a nM
Citation
 Yu, Z; Brannigan, JA; Rangachari, K; Heal, WP; Wilkinson, AJ; Holder, AA; Leatherbarrow, RJ; Tate, EW Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase. Medchemcomm 6:1767-1772 (2016) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase 1
Synonyms:
Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:
Enzyme
Mol. Mass.:
56814.10
Organism:
Homo sapiens (Human)
Description:
P30419
Residue:
496
Sequence:
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
  
Inhibitor
Name:
BDBM50135488
Synonyms:
CHEMBL3754571
Type:
Small organic molecule
Emp. Form.:
C22H21N5O2
Mol. Mass.:
387.4344
SMILES:
C(c1noc(n1)-c1cccnc1OC1CCNCC1)c1cccc2ncccc12
Structure:
Search PDB for entries with ligand similarity: