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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM50160399
Substrate
n/a
Meas. Tech.
ChEBML_1566145
IC50
>100000±n/a nM
Citation
 Cerón-Romero, L; Paoli, P; Camici, G; Flores-Morales, V; Rios, MY; Ramírez-Espinosa, JJ; Hidalgo-Figueroa, S; Navarrete-Vázquez, G; Estrada-Soto, S In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives. Bioorg Med Chem Lett 26:2018-22 (2016) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM50160399
Synonyms:
CHEMBL3786595
Type:
Small organic molecule
Emp. Form.:
C32H52O3
Mol. Mass.:
484.7535
SMILES:
[H][C@]12CC[C@]3([H])[C@@]4(C)CCC5(OCCO5)C(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@@]1(CO)CCC(C)(C)C=C21 |r,t:40|
Structure:
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