Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50161248
Substrate
n/a
Meas. Tech.
ChEMBL_1566191 (CHEMBL3788097)
EC50
>20000±n/a nM
Citation
 Xue, YTang, JMa, XLi, QXie, BHao, YJin, HWang, KZhang, GZhang, LZhang, L Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists. Eur J Med Chem 115:94-108 (2016) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50161248
Synonyms:
CHEMBL3786604
Type:
Small organic molecule
Emp. Form.:
C26H28ClN3O5
Mol. Mass.:
497.971
SMILES:
Cl.CCOC(=O)c1cc(C(=O)c2ccccc2O)n2ccc(cc12)C(=O)N[C@H]1CN2CCC1CC2 |r,wD:27.28,(9.33,-.31,;5.44,-4.72,;4.24,-4.47,;3.75,-3.01,;2.24,-2.7,;1.42,-3.62,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.24,2.7,;1.42,3.61,;3.75,3.01,;4.77,1.86,;6.28,2.18,;6.76,3.64,;5.74,4.79,;4.23,4.48,;3.41,5.4,;.3,.77,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;-3.72,-1.53,;-4.78,-.91,;-3.72,-3.07,;-5.06,-3.84,;-6.44,-2.99,;-7.84,-3.78,;-7.86,-5.4,;-6.46,-6.24,;-5.04,-5.46,;-5.76,-4.38,;-6.87,-4.97,)|
Structure:
Search PDB for entries with ligand similarity: