Reaction Details Report a problem with these data
Target
G-protein coupled receptor 4
Ligand
BDBM50175290
Substrate
n/a
Meas. Tech.
ChEMBL_1581084 (CHEMBL3813382)
pH
7.2±n/a
IC50
67±n/a nM
Comments
extracted
Citation
 Fukuda, H; Ito, S; Watari, K; Mogi, C; Arisawa, M; Okajima, F; Kurose, H; Shuto, S Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction. ACS Med Chem Lett 7:493-7 (2016) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 4
Synonyms:
G-protein coupled receptor 4 | G-protein coupled receptor 4 (GPR4) | GPR4 | GPR4_HUMAN
Type:
Enzyme
Mol. Mass.:
40994.40
Organism:
Human
Description:
P46093
Residue:
362
Sequence:
MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPPAQ
  
Inhibitor
Name:
BDBM50175290
Synonyms:
CHEMBL3810385
Type:
Small organic molecule
Emp. Form.:
C31H37N5
Mol. Mass.:
479.659
SMILES:
CCc1nc2c(C)cc(C)nc2n1Cc1ccc2Nc3ccc(CN4CCCCC4)cc3CCc2c1
Structure:
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