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Target
Platelet-activating factor acetylhydrolase IB subunit alpha2
Ligand
BDBM50132713
Substrate
n/a
Meas. Tech.
ChEMBL_1589931 (CHEMBL3830921)
IC50
72±n/a nM
Citation
 Sarma, BK; Liu, X; Kodadek, T Identification of selective covalent inhibitors of platelet activating factor acetylhydrolase 1B2 from the screening of an oxadiazolone-capped peptoid-azapeptoid hybrid library. Bioorg Med Chem 24:3953-3963 (2016) [PubMed]  Article 
Target
Name:
Platelet-activating factor acetylhydrolase IB subunit alpha2
Synonyms:
PA1B2_HUMAN | PAF acetylhydrolase 30 kDa subunit | PAF-AH 30 kDa subunit | PAF-AH subunit beta | PAFAH subunit beta | PAFAH1B2 | PAFAHB | Platelet-activating factor acetylhydrolase IB subunit beta
Type:
PROTEIN
Mol. Mass.:
25565.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_18054
Residue:
229
Sequence:
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDTDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA
  
Inhibitor
Name:
BDBM50132713
Synonyms:
Arachidonic acid derivative | CHEMBL113262 | Methyl arachidonoyl fluorophophonate | methyl ((5Z,8Z,11Z,14Z)-2-Icosa-5,8,11,14-tetraenyl)phosphonofluoridoate | methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenylphosphonofluoridate | methyl -icosa-5,8,11,14-tetraenylphosphonofluoridate | methyl(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenylphosphonofluoridate | methylarachidonyl fluorophosphonate
Type:
Small organic molecule
Emp. Form.:
C21H36FO2P
Mol. Mass.:
370.4815
SMILES:
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC
Structure:
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