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Target
Platelet-activating factor acetylhydrolase IB subunit alpha2
Ligand
BDBM50188237
Substrate
n/a
Meas. Tech.
ChEMBL_1589931 (CHEMBL3830921)
IC50
63000±n/a nM
Citation
 Sarma, BK; Liu, X; Kodadek, T Identification of selective covalent inhibitors of platelet activating factor acetylhydrolase 1B2 from the screening of an oxadiazolone-capped peptoid-azapeptoid hybrid library. Bioorg Med Chem 24:3953-3963 (2016) [PubMed]  Article 
Target
Name:
Platelet-activating factor acetylhydrolase IB subunit alpha2
Synonyms:
PA1B2_HUMAN | PAF acetylhydrolase 30 kDa subunit | PAF-AH 30 kDa subunit | PAF-AH subunit beta | PAFAH subunit beta | PAFAH1B2 | PAFAHB | Platelet-activating factor acetylhydrolase IB subunit beta
Type:
PROTEIN
Mol. Mass.:
25565.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_18054
Residue:
229
Sequence:
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDTDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA
  
Inhibitor
Name:
BDBM50188237
Synonyms:
CHEMBL3828744
Type:
Small organic molecule
Emp. Form.:
C68H84BrClN18O18S
Mol. Mass.:
1588.926
SMILES:
COCCN(CC(=O)N(CCCCN)CC(=O)N(CCCCN)CC(N)=O)C(=O)CN(NC(=O)c1ccc(OC)cc1)C(=O)CN(NC(=O)Nc1ccccc1)C(=O)CN(NC(=O)c1ccc(Cl)cc1)C(=O)CN(NC(=O)CCOC)C(=O)CN(C)C(=O)Cn1nc(oc1=O)-c1ccc(s1)-c1ccc(Br)cc1
Structure:
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