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Target
Thymidine phosphorylase
Ligand
BDBM193765
Substrate
n/a
Meas. Tech.
ChEMBL_1633216 (CHEMBL3876008)
IC50
3200±n/a nM
Citation
 Bera, H; Chigurupati, S Recent discovery of non-nucleobase thymidine phosphorylase inhibitors targeting cancer. Eur J Med Chem 124:992-1003 (2016) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
TYPH_ECOLI | TdRPase | Thymidine Phosphorylase (TP) | deoA | tpp | ttg
Type:
Enzyme
Mol. Mass.:
47198.54
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
440
Sequence:
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE
  
Inhibitor
Name:
BDBM193765
Synonyms:
(E)-5-((2-(quinoxalin-2-yl)hydrazono)methyl)benzene-1,2,4-triol (18)
Type:
Small organic molecule
Emp. Form.:
C15H12N4O3
Mol. Mass.:
296.2808
SMILES:
Oc1cc(O)c(\C=N\Nc2cnc3ccccc3n2)cc1O
Structure:
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