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Target
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Ligand
BDBM50231793
Substrate
n/a
Meas. Tech.
ChEMBL_1645572 (CHEMBL3994501)
EC50
94±n/a nM
Citation
 Li, L; Jiang, X; Huang, S; Ying, Z; Zhang, Z; Pan, C; Li, S; Wang, X; Zhang, Z Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment. ACS Med Chem Lett 8:407-412 (2017) [PubMed]  Article 
Target
Name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Synonyms:
1.3.5.1 | Iron-sulfur subunit of complex II | SDH | SDH1 | SDHB | SDHB_HUMAN | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Type:
PROTEIN
Mol. Mass.:
31643.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117429
Residue:
280
Sequence:
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
  
Inhibitor
Name:
BDBM50231793
Synonyms:
CHEMBL4082074 | US11725000, Compound 110
Type:
Small organic molecule
Emp. Form.:
C19H16F3N3O4S
Mol. Mass.:
439.408
SMILES:
COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)cc1
Structure:
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