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Target
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Ligand
BDBM50231814
Substrate
n/a
Meas. Tech.
ChEMBL_1645575 (CHEMBL3994504)
EC50
0.230000±n/a nM
Citation
 Li, L; Jiang, X; Huang, S; Ying, Z; Zhang, Z; Pan, C; Li, S; Wang, X; Zhang, Z Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment. ACS Med Chem Lett 8:407-412 (2017) [PubMed]  Article 
Target
Name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Synonyms:
1.3.5.1 | Iron-sulfur subunit of complex II | SDH | SDH1 | SDHB | SDHB_HUMAN | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Type:
PROTEIN
Mol. Mass.:
31643.02
Organism:
Human
Description:
ChEMBL_117429
Residue:
280
Sequence:
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
  
Inhibitor
Name:
BDBM50231814
Synonyms:
CHEMBL4078870 | US11725000, Compound 289
Type:
Small organic molecule
Emp. Form.:
C33H37F3N4O6S
Mol. Mass.:
674.73
SMILES:
COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(=O)NC23CC4CC(CC(C4)C2)C3)C(F)(F)F)cc1OC |TLB:28:29:32.31.36:34,THB:30:31:34:38.29.37,30:29:32.31.36:34,37:29:32:36.35.34,37:35:32:38.30.29,28:29:32:36.35.34|
Structure:
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