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Target
Bromodomain-containing protein 9
Ligand
BDBM50234926
Substrate
n/a
Meas. Tech.
ChEMBL_1654193 (CHEMBL4003559)
IC50
1995±n/a nM
Citation
 Humphreys, PG; Bamborough, P; Chung, CW; Craggs, PD; Gordon, L; Grandi, P; Hayhow, TG; Hussain, J; Jones, KL; Lindon, M; Michon, AM; Renaux, JF; Suckling, CJ; Tough, DF; Prinjha, RK Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J Med Chem 60:695-709 (2017) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 9
Synonyms:
BRD9 | BRD9_HUMAN | Bromodomain-containing protein 9 | Rhabdomyosarcoma antigen MU-RMS-40.8
Type:
PROTEIN
Mol. Mass.:
66994.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108000
Residue:
597
Sequence:
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLGKVKKELDPDDSHLNLDETTKLLQDLHEAQAERGGSRPSSNLSSLSNASERDQHHLGSPSRLSVGEQPDVTHDPYEFLQSPEPAASAKT
  
Inhibitor
Name:
BDBM50234926
Synonyms:
CHEMBL4101945
Type:
Small organic molecule
Emp. Form.:
C15H17ClN4O
Mol. Mass.:
304.775
SMILES:
CN1CCc2c(C1)cccc2Nc1cnn(C)c(=O)c1Cl
Structure:
Search PDB for entries with ligand similarity: