Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50239048
Substrate
n/a
Meas. Tech.
ChEMBL_1664963 (CHEMBL4014759)
EC50
7.50±n/a nM
Citation
Xu, J; Lin, S; Myers, RW; Addona, G; Berger, JP; Campbell, B; Chen, HS; Chen, Z; Eiermann, GJ; Elowe, NH; Farrer, BT; Feng, W; Fu, Q; Kats-Kagan, R; Kavana, M; Malkani, S; McMasters, DR; Mitra, K; Pachanski, MJ; Tong, X; Trujillo, ME; Xu, L; Zhang, B; Zhang, F; Zhang, R; Parmee, ER Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus. Bioorg Med Chem Lett 27:2069-2073 (2017) [PubMed] Article
More Info.:
Target
Name:
Hexokinase-4
Synonyms:
Gck | HXK4_RAT | Hexokinase type IV
Type:
PROTEIN
Mol. Mass.:
52101.81
Organism:
Rattus norvegicus
Description:
ChEMBL_1279785
Residue:
465
Sequence:
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ