Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM87329
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
7259±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
HHV-1
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM87329
Synonyms:
4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitro-benzenesulfonamide | 4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitrobenzenesulfonamide | 4-(1,3-benzothiazol-2-ylthio)-3-nitro-benzenesulfonamide | 4-(1,3-benzothiazol-2-ylthio)-3-nitrobenzene-1-sulfonamide | 4-(1,3-benzothiazol-2-ylthio)-3-nitrobenzenesulfonamide | MLS000849941 | SMR000455959 | cid_2807234
Type:
Small organic molecule
Emp. Form.:
C13H9N3O4S3
Mol. Mass.:
367.423
SMILES:
NS(=O)(=O)c1ccc(Sc2nc3ccccc3s2)c(c1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: