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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM78233
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM78233
Synonyms:
4-(2-methylanilino)-1-phenyl-1,3-diazaspiro[4.5]dec-3-ene-2-thione | 4-(o-toluidino)-1-phenyl-1,3-diazaspiro[4.5]dec-3-ene-2-thione | 4-[(2-methylphenyl)amino]-1-phenyl-1,3-diazaspiro[4.5]dec-3-ene-2-thione | 4-[(2-methylphenyl)imino]-1-phenyl-1,3-diazaspiro[4.5]decane-2-thione | MLS000699821 | SMR000225185 | cid_828256
Type:
Small organic molecule
Emp. Form.:
C21H23N3S
Mol. Mass.:
349.492
SMILES:
Cc1ccccc1NC1=NC(=S)N(c2ccccc2)C11CCCCC1 |t:9|
Structure:
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