Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90246
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90246
Synonyms:
4-[1-oxo-2-[(1-propyl-2-benzimidazolyl)thio]ethyl]-1,3-dihydroquinoxalin-2-one | 4-[2-(1-propylbenzimidazol-2-yl)sulfanylacetyl]-1,3-dihydroquinoxalin-2-one | 4-[2-(1-propylbenzimidazol-2-yl)sulfanylethanoyl]-1,3-dihydroquinoxalin-2-one | 4-[2-[(1-propylbenzimidazol-2-yl)thio]acetyl]-1,3-dihydroquinoxalin-2-one | MLS000334918 | SMR000249676 | cid_3331758
Type:
Small organic molecule
Emp. Form.:
C20H20N4O2S
Mol. Mass.:
380.463
SMILES:
CCCn1c(SCC(=O)N2CC(=O)Nc3ccccc23)nc2ccccc12
Structure:
Search PDB for entries with ligand similarity: